|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, ClC-2 expression is markedly reduced in the colon of human patients with ulcerative colitis.
|
24030525 |
2013 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
AngII-induced HBVSMC proliferation, migration and invasion were significantly attenuated by ClC-2 downregulation.
|
29988306 |
2018 |
|
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Parasitic infection
|
0.010 |
Biomarker
|
group |
BEFREE |
The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown.
|
29576976 |
2018 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The involvement of ruminant-specific galectin-11 (LGALS-11) and galectin-14 (LGALS-14) has been postulated to play important roles in protective immune responses against parasitic infection; however, their ligands are unknown.
|
29576976 |
2018 |
|
Opioid-Induced Constipation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Lubiprostone is a ClC-2 chloride channel activator approved for the treatment of chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC) in adults and irritable bowel syndrome with constipation (IBS-C) in women.
|
28849329 |
2017 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ClC-2 mRNA level was significantly increased in patients with non-alcoholic steatohepatitis, which positively correlated with the plasma levels of alanine transaminase (ALT), aspartate transaminase (AST) and insulin.
|
29550812 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lack of ClC-2 Alleviates High Fat Diet-Induced Insulin Resistance and Non-Alcoholic Fatty Liver Disease.
|
29550812 |
2018 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
We assessed the localisation of ClC-2 with immunohistochemistry and electron microscopy in post-mortem human brains of individuals without neurological disorders.
|
23707145 |
2013 |
|
Miscarriage
|
0.310 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Miscarriage
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Gal-13 and Gal-14 are primarily expressed by the syncytiotrophoblast at the maternal-fetal interface in the first trimester, and their placental expression is decreased in miscarriages compared to first-trimester controls.
|
31275299 |
2019 |
|
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS
|
0.030 |
Biomarker
|
disease |
BEFREE |
GlialCAM brings MLC1 and the ClC-2 Cl(-) channel to cell-cell junctions, even though the role of ClC-2 in MLC disease remains incompletely understood.
|
23793458 |
2013 |
|
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS
|
0.030 |
Biomarker
|
disease |
BEFREE |
Co-expression of the adhesion molecule GlialCAM, which forms a tertiary complex with ClC-2 and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1), rescued the functional expression of the mutant by modifying its gating properties.
|
28905383 |
2017 |
|
MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data unmask an unforeseen functional relationship between MLC1 and ClC-2 in vivo, which is probably mediated by GlialCAM, and suggest that ClC-2 participates in the pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts.
|
24647135 |
2014 |
|
Lung diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Fisher's analysis within this data set, did not demonstrate a significant relationship between the severity of lung disease and SNPs in the CLC-2 gene.
|
15507145 |
2004 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Modified AS1411-aptamer suppressed HCC cell growth in vitro and in vivo by up-regulating galectin-14 expressions.
|
27494117 |
2016 |
|
Leukoencephalopathy
|
0.030 |
AlteredExpression
|
group |
BEFREE |
GlialCAM expression affects expression of MLC1, ClC-2 and aquaporin4, indicating that abnormal interplay between these proteins is a disease mechanism in megalencephalic leukoencephalopathy with cysts.
|
28695146 |
2017 |
|
Leukoencephalopathy
|
0.030 |
Biomarker
|
group |
BEFREE |
Defects in the astrocytic membrane protein MLC1, the adhesion molecule GlialCAM or the chloride channel ClC-2 underlie human leukoencephalopathies.
|
24647135 |
2014 |
|
Leukoencephalopathy
|
0.030 |
Biomarker
|
group |
BEFREE |
Depolarization causes the formation of a ternary complex between GlialCAM, MLC1 and ClC-2 in astrocytes: implications in megalencephalic leukoencephalopathy.
|
28398517 |
2017 |
|
Leukodystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
GlialCAM, a regulatory subunit of ClC-2 in glial cells and involved in the leukodystrophy megalencephalic leukoencephalopathy with subcortical cysts (MLC), increases the activity of a ClC-2 mutant by affecting ClC-2 gating and by stabilising the mutant at the plasma membrane.
|
28905383 |
2017 |
|
Leukodystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.
|
24647135 |
2014 |
|
Leukodystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Mutations in the genes encoding the astrocytic protein MLC1, the cell adhesion molecule GlialCAM or the Cl(-) channel ClC-2 underlie human leukodystrophies.
|
26033718 |
2015 |
|
Irritable bowel syndrome with constipation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Lubiprostone is a ClC-2 chloride channel activator approved for the treatment of chronic idiopathic constipation (CIC) and opioid-induced constipation (OIC) in adults and irritable bowel syndrome with constipation (IBS-C) in women.
|
28849329 |
2017 |
|
Idiopathic generalized epilepsy
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To test for a potential pathophysiological impact of ClC-2 regulation by ATP, we studied ClC-2 channels carrying naturally occurring sequence variants found in patients with idiopathic generalized epilepsy, G715E, R577Q, and R653T.
|
23632988 |
2013 |
|
Idiopathic generalized epilepsy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Three different mutations in the CLCN2 gene, encoding the voltage-dependent homodimeric ClC-2 channel, have been associated with idiopathic generalized epilepsy (IGE).
|
15252188 |
2004 |